Email: bohu@nccu.edu
Molecular mechanism of intestinal metaplasia in the esophagus (Barrett's esophagus): The goal of this project is to study the roles of gastroesophageal refluxate (acid and bile acids), genetic and epigenetic pathways in the development of Barrett's esophagus, the premalignant lesion of esophageal adenocarcinoma, in cell culture, animal models, and humans. Current studies focus on the functions of a group of differentiation-related transcription factors(cdx1,cdx2) in intestinal metaplasia in both cell culture and transgenic models (swine and zebrafish).
Bo Hu, Hong GQ, Li ZX , Xu J , Zhu ZY and Li L. Expression of VCA and EBNA1 genes of Epstein-Barr virus in Pichia pastoris and application of the products in a screening test for patients with Nasopharyngeal carcinoma. Biotechnology and applied biochemistry 2007;47,59-69.
Bo Hu, Liang MJ, Hong GQ, Li ZX, Zhu ZY and Li L. Expression of hepatitis B virus S gene in Pichia pastorios and application of the product for detection of anti-HBs antibody. Journal of Biochemistry and Molecular Biology 2005; 38 (6): 683-689.
Bo Hu, Ye SX, Chen ZC, Luo MQ and Li ZX. Changes and clinical significance of IL-8,Il-10 and TNF-a levels in acute myocardial infarction patients. Chinese Journal of Modern Medicine 2006; 16 (7): 1052-1054.
Bo Hu, Chen ZC, Luo MQ, Wu ZH and Xu J. Changes and clinical significance of TNFa, IL-6 levels in nephrotic syndrome patients. Guangdong Medical Journal 2006; 27 (3): 355-356.
Bo Hu, Xu J, Chen ZC, Wu ZH and Luo MQ. Changes and clinical significance of IL-2, TNFa and IL-6 levels in type 2 diabetes mellitus patients. Guangdong Medical Journal 2006; 27 (5): 735-736.
Bo Hu, Chen ZC, Luo MQ, Xu J and Wu ZH. Changes and clinical meaning of tumor necrosis factor-a and interleukin-10 in acute pancreatitis. China Journal of Modern Medicine 2005; 15 (4): 560-562.
Bo Hu, Li ZX, Zhou YQ, Liang MJ, Luo MQ and Li L. Cloning and insertion of recombinant of HIV envelope protein into baculovirus transfer vector. Immunological Journal 2003; 19 (2): 127-131.
Bo Hu, Zhou X, Liang MJ, Li ZX and Liang JY. (TTTTA)n polymorphism analysis in the 5’control region of apolipoprotein (a) gene in patients with coronary heart disease and the association with serum lipid level. Chinese Journal of Pathophysiology 2003; 19 (2): 215-217.
Bo Hu, Zhong RH, Liang MJ and Li L. Measurement of levels of serum tumor necrosis factor а,interleukin-1b and interleukin-6 in viral hepatitis,liver cirrhosis and liver cancer patients. Chinese Journal of Immunology 2002; 18 (sup): 43-47
Bo Hu, Zhou X, Li L and Li X. A preliminary study of pentanucleotide repeat polymorphism of apolipoprotein(a) gene in coronary atherosclerotic heart disease. Chinese Journal of Medical Genetics 2002; 19 (1): 46-48.
Bo Hu, Zhou X, Li L and Zheng F. Effects of a pentanucleotide repeat polymorphism of the apolipoprotein (a) gene on serum levels of lipoproteins in healthy Han population. Chinese Journal of Pathophysiology 2001; 17 (9): 866-869.
Bo Hu, Zhou X, Li X and Liang MJ. A TTTTA pentanucleotide Repeat polymorphism of Apolipoprotein (a) Gene in Patient with Cerebral Infarction. Chinese Journal of Arteriosclerosis 2001; 9 (3): 231-234.
Bo Hu, Zhou X and Shao H. A pentanucleotide repeat sequence genotype of apolipoprotein (a). Chinese Journal of Laboratory Medicine 2000; 23 (2): 83-86.
Bo Hu, Zhou X, Shao H, Zheng F and Lu MQ. Relationship between pentanucleotide repeats polymorphism of the apolipoprotein (a) gene and atherosclerosis cerebral infarction in Han nationality. Chinese Journal of Neurology 2000; 33 (3): 172-175.
Bo Hu, Liang JY and Zhou X. Detection of IL-1β, IL-6 and SAA levels in rheumatoid arthritis patients. Central China Medical Journal 2000; 24 (6): 290-291.
Li ZX, Xi Y, Hong GQ, Bo Hu, Liang MJ, Xu J and Li L. Expression of hepatitis B virus e gene synthesized in pichia pastoris and the immunological characterization of the product. Chinese Journal of Laboratory Medicine 2006; 29 (9): 807-812.
Zhou YQ, Zhang TT, Bo Hu, Li L and Huang J. Expression of the N-terminal fragment gene of bactericidal/permeability increasing protein by E.coli and its initial clinical usage. Chinese Journal of Immunology 2005; 21 (5): 385-389.
Li ZX, Liang MJ, Li L, Bo Hu and Zhu ZY. Expression of hepatitis B virus core gene in pichia pastoris. Chinese Journal of Pathophysiology 2004; 20 (20): 2320-2324.
Shao H, Zhou X and Bo Hu. Research of CGG Triplet Repeat Polymorphism of Very Low Density Lipoprotein Receptor Gene. Basic Medical Science and Clinic 2000; 20 (4): 315-317.
Shao H, Zhou X, Li Y and Bo Hu. Correlation between CGG Triplet Repeat Polymorphism of Very Low Density Lipoprotein Receptor Gene and Coronary Heart Disease. Chinese Journal of Arteriosclerosis 2000; 8 (2): 169-171.
Liang MJ, Bo Hu, Li ZX , Cheng ZC and Zhang GQ. A primary study on SAA levels in Rheumatoid Arthritis patients. Journal of Clinical Laboratory Science 2001; 19 (2): 114