formerly M. Audrey Rudd
Associate Professor , Cardiovascular Research Program; Biology Dept.
Chair, BBRI Education Committee
Adjunct Assistant Professor, Duke University Department of Medicine
Email: mpointer@nccu.edu
B.S., Department of Biology at North Carolina Central University in 1974;
Ph.D. in Physiology and Pharmacology at Wake Forest University School of Medicine in 1983;
Post doctorate in Renal Micropuncture Unit at University of North Carolina at Chapel Hill School of Medicine 1983-1986
Post-doctorate in Division of Vascular Medicine at Brigham and Women’s Hospital at Harvard Medical School 1986-1988.
My research focuses on two basic questions: 1) What is/are the mechanism(s) of salt-induced hypertension?, and 2) What are the processes involved in the organ damage, e.g., renal disease and myocardial infarction, associated with hypertension? Since approximately 75% of African Americans who are hypertensive are salt-sensitive and African Americans have a 3 to 10 times greater incidence of renal damage, my particular interest is that of salt-sensitive hypertension and the associated renal injury accompanying this form of hypertension. To address these questions, we use animal models of salt-sensitive hypertension and employ microarray molecular analysis for examining differential gene expression, Western analysis for determining differential protein expression, and basic physiological tools for assessing renal and cardiovascular function in normal, hypertensive, and hypertensive animals treated with various pharmacologic interventions.
-
Responsible Conduct in Research
-
BIOL 4620: Bioethics
- BIOG 5400: Physiology Pharmacology I
- BIOG 5800: Research in Biology
- BIOG 5900: Thesis
- BIOG 5401: Physiology Pharmacology II
- Duke University Center for Human Genetics and Behavioral Medicine
- Elizabeth Hauser, Ph.D
- Simon Gregory, PhD
- Redford Williams, MD
- Keith Whitfield, PhD
- Reading Mysteries
- Playing puzzle games (Sudoku and Mahjong)
- Coin Collecting
Pointer MA, Livingston JN, Yancey S, McClelland MK,Bukoski RD (deceased) Psychosocial Factors Contribute to Resting Blood Pressure in African Americans Ethnicity & Disease (in press).
Eley S, Allen C, Williams C, Bukoski RD*, Pointer MA, Action of Thiazide on Renal Interstitial Calcium Am J Hypertension * deceased (in press).
Maitland K, Bridges L, Davis W, Loscalzo J, Pointer MA* Different Effects of Angiotensin Receptor Blockade on End-organ Damage in Salt-dependent and -independent Hypertension Circulation 114:905-91, 2006.
* note: M. Audrey Rudd name change to Mildred A. Pointer
Pointer MA*, Is central nitric oxide essential in hypertension? Journal of Hypertension 23:1637-1638, 2005.
* note name change from M. Audrey Rudd to Mildred A. Pointer.
Bátkai S, Pacher P, Osei-Hyiaman D, Radaeva S, Liu J, Harvey-White J, Offertáler L, Mackie K, Rudd MA, Bukoski RD, Kunos G Endocannabinoids acting at CB1 receptors regulate cardiovascular function in hypertension 2004; Circulation 110:1996-2002.
Palmer CE, Rudd MA, Bukoski RD. Renal interstitial Ca2+ during sodium loading of normotensive and Dahl-salt hypertensive rats 2003; Am J Hypertens16:771-776.
Pamarthi MF. Rudd MA, Bukoski RD Normal perivascular sensory dilator nerve function in arteries of Zucker diabetic fatty rats Am J Hypertension 2002;15:310-315.
Jones JE, Zhang Y-Y, Mendes L, Rudd MA, Russo G, Loscalzo J. Serial noninvasive assessment of progressive pulmonary hypertension in a rat model. Am J Phy 2002; 283:H364-H371.
Trolliet MR, Rudd MA, Loscalzo J Oxidative stress and renal dysfunction in salt-sensitive hypertension Kidney Blood Pressure Research 2001; 24:116-123.
Eberhardt RT, Forgione MA, Cap A, Rudd MA, Trolliet MT, Heydrick S, Stark R, Klings ES, Moldovan N, Yaghoubi M, Goldschmidt P, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in mild hyperhomocystemia JCI 2000; 106: 483-491.