Assistant Professor, Human Nutrition Research Program at NC Research Campus
Email: ssang@nccu.edu
My overall research goals are to study dietary exposure markers using metabolomic approach and to identify novel bioactive natural products that can be used in functional foods and dietary supplements to prevent chronic diseases such as cancer and diabetes. Specific projects in my lab involve:
- using dietary compounds and their metabolites to assess human dietary intake;
- studying how human metabolite profile is affected by dietary consumption using metabolomic approach;
- purifying and identifying bioactive components from herbal medicine and functional foods;
- standardization and quality control of herbal medicine and functional foods;
- studying the bioavailability and biotransformation of bioactive natural products in animals and humans;
- studying the preventive effects of dietary polyphenols, such as tea catechins and apple polyphenols on the development of diabetic complications focusing on the traping of reactive dicarbonyl compounds and the formation of Advanced Glycation End Products (AGEs) using in vitro and animal models;
- developing new chemopreventive agents from dietary sources, such as gingerols and shogaols from ginger, pterostilbene from blueberry, theaflavins from black tea, and wheat bran oil from wheat bran using in vitro and animal models.
Sang, S.M.*; Lee, M.J.; Yang, I.; Buckley, B.; Yang, C.S. Human Urinary Metabolite Profile of Tea Polyphenols analyzed by Liquid Chromatography/electrospray Ionization Tandem Mass Spectrometry with Data-dependent Acquisition. Rapid Commun Mass Spectrom 2008 22(10):1567-1578. (* Corresponding author)
Lambert, J.D.; Sang, S.M.; Yang, C.S. N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct. Free Radical Bio. Med. 2008, 44(6), 1069-1074.
Sang, S.M.*; Shao, X.; Bai, N.; Yang, C.S.; Ho, C.T. Tea Polyphenol (-)-Epigallocatechin 3-Gallate: a New Trapping Agent of Reactive Dicarbonyl Species. Chem. Res. Toxicol. 2007, 20(12):1862-1870. (* Corresponding author)
Sang, S.M.; Yang, H.; Buckley, B.; Ho, C.T.; Yang, C.S. Autoxidative quinone formation in vitro and metabolite formation in vivo from tea polyphenol (-)-epigallocatechin-3-gallate: studied by real-time mass scanning combined with tandem mass ion mapping. Free Radical Bio. Med. 2007, 43(3), 362-371.
Sang, S.M.; Ju, J.; Lambert, J.D.; Yong, L.; Hong, J.; Bose, M.; Wang, S.; Bai, N.S.; He, K.; Reddy, B.; Ho, C.T.; Yang, C.S. Wheat bran oil and its fractions inhibit human colon cancer cell growth and intestinal tumorigenesis in Apcmin/+ mice. J. Agric. Food Chem. . 2006, 54(26), 9792-9797.
Lambert, J.D.; Sang, S.M.; Hong, J.; Kwon, S.J.; Lee, M.J.; Ho, C.T.; Yang, C.S. Peracetylation as a Means of Enhancing In vitro Bioactivity and Bioavailability of Epigallocatechin-3-gallate. Drug Metab. Dispos. 2006, 34(12), 2111-2116.
Sang, S.M.; Lambert, J.D.; Yang, C.S. Bioavailability and stability issues in understanding the cancer preventive effects of tea polyphenols. J. Sci. Food Agric. 2006, 86(14), 2256-2265.
Sang, S.M.; Lambert, J.D.; Tian, S.Y.; Hong, J.; Lee, M. J.; Stark, R.E.; Ho, C.T.; Yang, C.S. Enzymatic Synthesis and Structure Identification of Thiol Conjugated (-)-Epigallocatechin Gallate and Their Urinary Level in Mice. Chem. Res. Toxicol. 2005,18(11), 1762-1769.
Sang, S.M.; Hou, Z.; Lambert, J.D.; and Yang, C.S. Redox Properties of Tea Polyphenols and Related Biological Activities. Antioxidants and Redox Signaling 2005, 7(11-12): 1704-14 .
Sang, S.M.; Lee, M. J.; Hou, Z.; Ho, C.T.; Yang, C.S. Stability of (-)-Epigallocatechin-3-Gallate in Biological Related Conditions. J. Agric. Food Chem. 2005,53(24), 9478-84.
Hou, Z.; Sang, S.M.; Lee, M.J.; Hong, J.; Chin, K.V.; and Yang, C.S. Mechanism of action of (-) Epigallocatechin-3-3gallate: Auto-oxidation dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. Cancer Res. 2005, 65(17), 8049-56.
Liao, C.H.; Sang, S.M.; Ho, C.T.; Lin, J.K. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. J. Cell Biochem. 2005, 96 (1), 155-169.
Sang, S.M.*; Yang, C.S.; Ho, C.T. Peroxidase-mediated Oxidation of Catechins Phytochemistry Reviews 2004; 3(1-2), 229-241. (* Corresponding author)
Sang, S.M.*; Tian, S.Y.; Stark, R.E.; Yang, C.S.; Ho, C.T. “New Dibenzotropolone Derivatives Characterized From Black Tea Using LC/MS/MS” Bioorg. Med. Chem. 2004; 12(11), 3009-3017. (* Corresponding author)
Sang, S.M.*; Lambert, J.; Tian, S.Y.; Hong, J.; Hou, Z.; Stark, R.E.; Rosen, R.T.; Yang, C.S.; Ho, C.T. Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities. Bioorg. Med. Chem. 2004; 12(2), 459-467. (* Corresponding author)
Sang, S.M.; Tian, S.Y.; Jhoo, J.W.; Wang, S.; Stark, R.E.; Rosen, R.T.; Yang, C.S.; Ho, C.T. Chemical Studies of the Antioxidant Mechanism of Theaflavins: Radical Reaction Products of Theaflavin digallate with Hydrogen peroxide. Tetrahedron Lett. 2003, 44(30), 5583-5587.
Sang, S.M.; Liu, G.M.; He, K.; Zhu, N.Q.; Dong, Z.G.; Zheng, Q.Y.; Rosen, R.T.; Ho, C.T. New Unusual Iridoids from the Leaves of Noni (Morinda citrifolia L.) Show Inhibitory Effect on Ultraviolet B-induced Transcriptional Activator Protein-1 (AP-1) Activity.Bioorg. Med. Chem. 2003, 11(12), 2499-2502.
Sang, S.M.; Li, G.L.; Tian, S.Y.; Lapsley, K.; Stark, R.E.; Pandey, R.K.; Rosen, R.T.; Ho, C.T. A unique diterpene glycoside from the nuts of Almond (Prunus amygdalus Batsch). Tetrahedron. Lett. 2003, 44(6), 1199-1202.
Sang, S.M.; Liao, C.H.; Pan, M.H.; Rosen, R.T.; Lin-Shiau, S.Y.; Lin, J.K.; Ho, C.T. Chemical studies on antioxidant mechanism of garcinol: structural identification of the reaction products of garcinol with peroxyl radicals and their antitumor activities. Tetrahedron. 2002, 58(51), 10095-10102.
Wang, M.F.; Sang, S.M.; Hwang, L.; Ho, C.T. (Editors) "Herbs: Challenges in Chemistry & Biology", Published by American Chemical Society (February 2006). ISBN 0841239304.2007, Young Scientist Award, ACS Division of Agricultural and Food Chemistry
2007, Travel award, Fourth International Scientific Symposium on Tea and Human Health
Ho, C.T.; Ghai, G.; Sang, S.M.; Jhoo, J.W.; Huang, M.T.; Rosen, R.T.; Dushenkov, S. Benzotropolone derivatives and modulation of inflammatory response. United States Patent Numbers: 7,087,790 B2. August 8, 2006 and 7,288,680. October 30, 2007.
- Editorial Board: The Open Natural Products Journal
- American Chemical Society
- American Society of Pharmacognosy
- Society of Chinese Biochemists in America