Cancer Research Program
Human cancer has long been known to have a multifactorial etiology, with biological, physical, or chemical agents being strongly implicated in triggering disease. A significant body of information has demonstrated that qualitative and/or quantitative changes occur in genes that are critical for the regulation of cell growth, differentiation, and proliferation. The JLC-BBRI toxicology/carcinogenesis program is studying cancer cause and prevention, placing particular emphasis on utilizing molecular/genetic strategies to better define the critical steps in carcinogenesis, and understand the interplay between genes and the environment. Applying single nucleotide polymorphism analysis to study racial, ethnic, and gender disparities represents another important focus of the JLC-BBRI toxicology/carcinogenesis research program. Areas of expertise include: biomarkers of disease; genetic polymorphisms; cause and prevention; and susceptibility to disease.
Key Personnel